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There are, however, several limitations to existing studies. Archie Campbell, Email: ku. Deary , 2, 3 and Riccardo E. Applications should be made to access generationscotland. Age and sex-adjusted linear regression models showed that the DNAm predictors, which were developed in GS, explained a small proportion of the phenotypic variance in educational attainment, total cholesterol, cholesterol ratios, and LDL with remnant cholesterol 0. Given that DNA methylation is highly predictive of smoking status [ 9 ], it may be the case that, should a single smoking-sensitive CpG feature in a DNAm predictor for another trait—here, education—then this drives a high correlation between the two DNAm predictors. Walker , 1 Qian Zhang , 4 Stewart W. Smoking-associated DNA methylation markers predict lung cancer incidence.

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